MIC values of selected spiramycin I derivatives, expressed in μg mL−1, and in μM, evaluated in the 0.5–128 μM range of concentrations.
| S. aureus ATCC25923 | S. aureus MRSA ATCC515992 | S. epidermidis ATCC12228 | B. subtilis ATCC6633 | |
|---|---|---|---|---|
| Spiramycin I | 53.96 [64] | 53.96 [64] | 13.49 [16] | 13.49 [16] |
| 1 | 7.40 [8] | 14.80 [16] | 3.70 [4] | 3.70 [4] |
| 2 | 3.77 [4] | 7.54 [8] | 3.77 [4] | 1.89 [2] |
| 3 | 7.75 [8] | 15.51 [16] | 7.75 [8] | 1.94 [2] |
| 4 | 7.63 [8] | 15.25 [16] | 3.81 [4] | 3.81 [4] |
| 5 | 14.85 [16] | 29.70 [32] | 7.43 [8] | 3.71 [4] |
| 6 | 7.76 [8] | 15.52 [16] | 7.76 [8] | 1.94 [2] |
| 9a | >128.42 [>128] | 16.05 [16] | 4.01 [4] | 4.01[4] |
| 10a | 8.02 [8] | 32.08 [32] | 4.01 [4] | 4.01 [4] |
| 10b | 16.04 [16] | 16.04 [16] | 8.02 [8] | 2.00 [2] |
| 11 | >133.12 [>128] | 33.30 [32] | 4.16 [4] | 8.32 [8] |
| 12 | 8.13 [8] | 16.27 [16] | 4.07 [4] | 4.07 [4] |
| 13 | 17.56 [16] | 35.12 [32] | 8.78 [8] | 4.39 [4] |
| 14 | 17.75 [16] | 17.75 [16] | 8.88 [8] | 4.44 [4] |
| 16 | 3.87 [4] | 7.75 [8] | 0.97 [1] | 0.97 [1] |
| 17 | 15.61 [16] | 62.44 [64] | 7.80 [8] | 15.61 [16] |
| 20 | 8.24 [8] | 32.97 [32] | 8.24 [8] | 2.06 [2] |
| Linezolid | 1.35 [4] | 2.67 [8] | 0.34 [1] | 0.17 [0.5] |