Extended_Data_Fig7. Enrichment of GWAS trait heritability mediated by enhancer methylation in 128 tissues/cell types.

a. GWAS heritability mediated by kidney methylation categorized as enhancers in 128 tissues/cell types. The x-axis shows the GWAS traits, while the y-axis shows tissue enhancers in kidney and 127 other tissue samples from the Roadmap project ChromHMM data. Gray, non-significant, while white to red indicates significant enrichment (nominal two-sided p < 0.05 calculated by MESC). Asterisk indicates ${h^2}_{med}$ enrichment passing FDR q < 0.05 (accounting for 4,352 tests for 128 enhancer CpG sets and 34 GWAS traits).

b. GWAS heritability mediated by blood methylation categorized as enhancers in 128 tissues/cell types. The x-axis shows the GWAS traits, while the y-axis shows tissue enhancers in kidney and 127 other tissue samples from the Roadmap project ChromHMM data. Gray, non-significant, while white to red indicates significant enrichment (nominal two-sided p < 0.05 calculated by MESC). Asterisk indicates ${h^2}_{med}$ enrichment passing FDR q < 0.05 (accounting for 4,352 tests for 128 enhancer CpG sets and 34 GWAS traits).