Table 2.

Functions of Four key Genes and the KEGG Pathway.

Genes	Location	Function	Super Pathway
FGG	chr4	Together with fibrinogen alpha (FGA) and fibrinogen beta (FGB), it polymerizes to form an insoluble fibrin matrix. It has a major function in hemostasis, as one of the primary components of blood clots.	Signaling downstream of RAS mutants
			Toll Like Receptor 3 (TLR3) Cascade
			Response to elevated platelet cytosolic Ca2+
			MAPK family signaling cascades
			Diseases of the immune system
PROCR	chr20	It binds activated protein C and enhances protein C activation via the thrombin–thrombomodulin complex.	Diseases of hemostasis
			Response to elevated platelet cytosolic Ca2+
			Cell surface interactions at the vascular wall
NPC1	chr18	It is an intracellular cholesterol transporter, which acts in concert with NPC2 and plays an important role in the egress of cholesterol from the endosomal.	Plasma lipoprotein assembly
			Cholesterol and sphingolipids transport
			Transport of inorganic cations/anions
			Degradation pathway of sphingolipids
ARHGAP24	chr4	It is an Rho GTPase-activating protein involved in cell polarity, cell morphology, and cytoskeletal organization.	Signaling via Rho GTPases
			RHOC GTPase cycle
			Signal transduction