Table 1.
Demographic and Baseline Disease Characteristics of Patients With Moderate (Score >1 to 2) or Severe (Score >2 to 3) LoS † at Baseline (Pooled SINUS-24/−52 Population).
| Moderate LoS at baseline (N = 106) | Severe LoS at baseline (N = 601) | P value | |
|---|---|---|---|
| Age, years | 52.6 (11.6) | 51.0 (13.0) | .2413 |
| Male, n (%) | 66 (62.3) | 360 (59.9) | .6466 |
| Prior sinonasal surgery, n (%) | 43 (40.6) | 404 (67.2) | <.0001 |
| Asthma, n (%) | 42 (39.6) | 380 (63.2) | <.0001 |
| NSAID-ERD, n (%) | 16 (15.1) | 185 (30.8) | .0010 |
| Severe rhinosinusitis (VAS >7 cm), n (%) | 47 (44.3) | 456 (75.9) | <.0001 |
| Severe rhinosinusitis (SNOT-22 > 50), n (%) | 30 (28.3) | 319 (53.1) | <.0001 |
| NPS (0−8) | 5.8 (1.2) | 6.0 (1.3) ‡ | .1594 |
| NC (0−3) | 1.9 (0.4) | 2.5 (0.6) | <.0001 |
| LMK-CT (0−24) | 16.3 (4.0) § | 18.9 (3.9) || | <.0001 |
| Rhinosinusitis VAS (0−10 cm) | 6.8 (2.2) | 8.1 (1.9) | <.0001 |
| SNOT-22 (0−110) | 40.9 (16.0) ¶ | 53.2 (20.8) †† | <.0001 |
Note: †28-day average.
‡
n = 598.
§
n = 104.
||
n = 589.
¶
n = 101.
††
n = 594.
Data are mean (standard deviation) unless otherwise specified.
P-values are from chi-square test for proportions and from t-test using Satterthwaite approximation for continuous variables (NC and SNOT-22).
LMK-CT, Lund-Mackay CT-scan score; LoS, loss of smell; NC, nasal congestion/obstruction score; NPS, nasal polyp score; NSAID-ERD, nonsteroidal antiinflammatory drug-exacerbated respiratory disease; SNOT-22, 22-item Sinonasal Outcome Test; VAS, visual analog scale.