Table 5.
Adhesion barrier types | Materials | Clinical evidence | Usability |
---|---|---|---|
Solid membranes | Oxidized regenerated cellulose membrane | Shown to be more effective than Seprafilm® in some pelvic operations when completely hemostatic Reported to have no significant anti-adhesion effect in certain animal models Significantly reduced the overall incidence of adhesions |
Applied more easily than Seprafilm because of its flexibility and good adhesiveness on wounds |
Solution (not available in Japan) | Icodextrin solution | Reduced adhesion in several procedures Adverse effects were reported such as extravasation, transient labial edema, incidence of small-bowel obstruction |
Solution can diffuse throughout the peritoneal cavity |
Hydrogel | Gel-based dextrin polymer | Reduced incidence and severity of peritoneal adhesion in laparotomy | Easily applied during laparoscopy using a dedicated sprayer |