FIGURE 2.

Comparison of MOP sequences from representative vertebrate species. A sequence alignment of the translated coding sequence from human (Homo sapiens), cow (Bos taurus), mouse (Mus musculus), chicken (Gallus gallus), western clawed frog (Xenopus (Silurana) tropicalis), zebra fish (Danio rerio), and Pacific hagfish (Eptatretus stoutii) is depicted above. Red bars denote transmembrane domains predicted by TsPred. However, in should be recognized that residues transitioning transmembrane domains to extracellular or intracellular domains are speculative and likely to be regulated by both posttranslational modifications and state of activation of the receptor. Blue triangles denote intron–exon boundaries. Conserved regions highlighted are the “DRY” motif (pink), “xRRxxRx” (green), and palmitoylation site (orange). Gaps are shown as “−.” The alignment is anchored to the hagfish sequence (red-dotted box)