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. Author manuscript; available in PMC: 2024 Dec 9.
Published in final edited form as: J Neurosci Res. 2020 Aug 23;100(1):19–34. doi: 10.1002/jnr.24682

FIGURE 3.

FIGURE 3

Homology model of hagfish MOP. The predicted structure of esMOP the mouse MOP bound to a morphinan agonist as a template (PDB: 4DKL) is shown. (a) esMOP exhibits typical seven-transmembrane structure and a conserved disulfide bond between TM-III and EL-II shown in red. (b) View of the ligand binding pocket from extracellular side shows conserved residues involved in polar interactions with the morphinan agonist, beta-funaltrexamine. W318, which prevents the binding of the DOP-specific agonist, Naltrindole, is shown in red