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. Author manuscript; available in PMC: 2024 Dec 9.
Published in final edited form as: Nat Genet. 2022 Jul 25;54(8):1090–1102. doi: 10.1038/s41588-022-01110-2

Extended Data Fig. 4. Secondary KO screen in Calu-3-Cas12a cells and comparison with Cas9-based screens.

Extended Data Fig. 4

a. Scatter plot showing the gene-level z-scores of genes when knocked out using Cas12a in Calu-3 cells. The top genes conferring resistance to SARS-CoV-2 are annotated and shown in blue. The top genes conferring sensitivity to SARS-CoV-2 are annotated and shown in red. (n = 684). Only one replicate is shown as the second replicate had low sequencing quality. b. Scatter plots showing mean z-scores comparing each Cas9 to Cas12a secondary KO screens for Calu-3 cells with top resistance and sensitization hits annotated. Pearson correlation, r, labeled (n = 600 each).