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. Author manuscript; available in PMC: 2024 Dec 9.
Published in final edited form as: Nat Genet. 2022 Jul 25;54(8):1090–1102. doi: 10.1038/s41588-022-01110-2

Extended Data Fig. 8. Impact of the identified antiviral genes on SARS-CoV-2 in Caco-2 and A549-ACE2 cells.

Extended Data Fig. 8

Caco-2-dCas9-VP64 (a) and A549-ACE2-dCas9-VP64 (b) cells were stably transduced to express 2 different sgRNAs (g1, g2) per indicated gene promoter, or negative controls (CTRL) and selected prior to SARS-CoV-2 mNG infection. The percentage of infected cells was scored 48 h later by flow cytometry. The mean of relative infection efficiencies are shown for 2 independent experiments. The red and dark red dashed lines represent 50% and 80% inhibition, respectively.