Trial	Number	Treatment	Additional treatment	Median/Mean follow up
Adams 1994c	14	Cimetidine 400mg po bd for 5 days pre‐operatively. Followed by 200mg iv q6hrly for 3 days post‐operatively.	Nil	30 months
	20	No placebo
Svendsen 1995	78	Cimetidine 400mg po bd for 2 years post‐operatively.	Nil	40 months
	70	Placebo
Finlay 1999	34	Cimetidine 400mg po bd for 5 days pre‐operatively.	Nil	14 months
	37	Cimetidine 800mg po bd for 5 days pre‐operatively.
	34	Placebo
Matsumoto 2002	34	Cimetidine 800mg po daily for 1 year post‐operatively.	8mg/m2 mitomycin C peri‐operatively, plus 200mg/m2 of oral 5‐FU daily for 1 year.	10.7 years
	30	No placebo
Nielsen 2002	282	Ranitidine 100mg IV intra‐operatively, followed by 150mg po bd for 5 years	Nil	6.8 years
	278	Placebo
Huang 2007	30	Cimetidine 200mg po qid for one week pre‐op, followed by 400mg IV bd for one week post‐op, then to continue 200mg po qid for 2 years.	6 cycles of 5‐Fluorouracil	54 months
	30	No placebo