Simon NCT00755235.

Trial name or title	Feasibility of Depression Care Management via E‐mail
Methods	RCT (Parallel)
Participants	Inclusion Criteria Male or Female, 18 years and older. Patient at Capitol Hill or Rainier clinics of Group Health Cooperative in Seattle. New prescription of an antidepressant, defined by an interval of at least 180 days since a previous antidepressant prescription. Indication of depression, defined by a visit diagnosis of major depressive disorder (Internal Classification of Diseases 9th Revision [ICD9] codes 296.2x or 296.3x) within 30 days of the first prescription. Has used secure messaging, or e‐mailing, at least twice in the last 12 months. Exclusion criteria Any diagnosis of psychotic disorder or bipolar disorder in the prior 2 years. Any prescription for mood stabilizer or antipsychotic medication in the prior 2 years.
Interventions	Participants will receive depression care management by secure messaging. Participants will receive electronic messages welcoming them and monitoring their antidepressant treatment. Care managers will use monitoring data to aid participants' physicians, coordinate physician follow‐ups, facilitate emergency care, and facilitate specialty referrals. Care managers will also provide motivation and education to participants.
Outcomes	Primary Outcome: Change in depression symptoms at 6 months as assessed by the 20‐Item Symptom Checklist Depression Scale (measured at baseline and 6 months). Secondary Outcome: Treatment satisfaction after 6 months of treatment.
Starting date	April 2009
Contact information	Gregory E Simon, MD, MPH. Group Health Cooperative Center for Health Studies. simon.g@ghc.org
Notes	This study is completed and pending submission for publication by the authors.