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. 2009 Jan 21;2009(1):CD006880. doi: 10.1002/14651858.CD006880.pub2

Koo 2005.

Methods Randomised clinical trial.
Generation of the allocation sequence: unclear. 
 Allocation concealment: unclear. 
 Blinding: inadequate. 
 Incomplete outcome data addressed:adequate. 
 Free from selective reporting: inadequate. 
 Free from baseline imbalance bias: adequate. 
 Free from early stopping bias: unclear. 
 Free from blocked randomisation bias: unclear. 
 Free from sponsor bias: unclear.
Participants Country: Korea. 
 Number randomised: 50. 
 Mean age: 52.7 years. 
 Females: 14 (28%). 
 Major liver resection: not stated. 
 Chronic liver disease: not stated. 
 Cirrhosis: not stated.
Inclusion criteria
Elective liver resection.
Exclusion criteria

  1. Cardiopulmonary diseases.

  2. Patients with dysphagia, hiatal hernia, or oesophageal disease.
Interventions Participants were randomly assigned to two groups.
Group 1: CUSA (n = 25) 
 Group 2: Clamp‐crush (n = 25).
Co‐interventions

  1. Vascular occlusion: no vascular occlusion.

  2. Low CVP: no.

  3. Hypoventilation: not stated.

  4. IV agents to decrease blood loss: not stated.

  5. Management of raw surface: not stated.
Outcomes The main outcome measures were peri‐operative morbidity, blood loss and transfusion requirements, transection time, and operating time.
Notes We requested further information from the authors regarding some outcomes in December 2006. We were unable to obtain the information.
Risk of bias
Bias Authors' judgement Support for judgement
Adequate sequence generation? Unclear risk B ‐ Unclear
Allocation concealment? Unclear risk B ‐ Unclear ("Randomization was performed by opening a sealed envelope before induction of anesthesia"). However, it was not clear whether randomisation was performed in blocks.
Blinding? 
 All outcomes High risk C ‐ Inadequate
Incomplete outcome data addressed? 
 All outcomes Low risk A ‐ Adequate
Review authors' comment: No post‐randomisation drop‐outs.
Free of selective reporting? High risk C ‐ Inadequate
Review authors' comment: Important outcomes were not reported.
Free of baseline imbalance bias? Low risk A ‐ Adequate ("Differences in the demographic data and duration of surgery between groups were not significant")
From from early stopping bias? Unclear risk B ‐ Unclear
Free from academic bias? Low risk A ‐ Adequate
Review author comment: No previous publication or conference report of a similar trial by the trial author was identified.
Free from sponsor bias? Unclear risk B ‐ Unclear