TABLE 4.
Growth Parameters According to the Age Group in Pediatric Patients Treated With Sofosbuvir/Velpatasvir: At Baseline (0), 3 Months After the End of Treatment (1) and 12 Months After the End of Treatment (2)
| Parameter | 0 | 1 | 2 | P (0 vs. 1) | P (0 vs. 2) | P (1 vs. 2) |
|---|---|---|---|---|---|---|
| Patients 6–11 yr of age (n=32) | ||||||
| BMI, kg/m2 | 16.8 (15.8 to 17.7) | 16.8 (15.8 to 17.7) | 17.3 (16.2 to 18.3) | 1.0 | 0.009 | 0.003 |
| BMI Z score | 0.13 (0.33 to 0.59) | 0.01 (−0.43 to 0.45) | 0.06 (−0.35 to 0.49) | 0.32 | 1.0 | 0.93 |
| Height, cm | 135.0 (131.6 to 138.7) | 138.1 (134.3 to 142.0) | 142.2 (138.1 to 146.5) | <0.0001 | <0.0001 | <0.0001 |
| Height Z score | 0.56 (0.26 to 0.86) | 0.56 (0.27 to 0.85) | 0.54 (0.18 to 0.91) | 1.0 | 1.0 | 1.0 |
| Weight, kg | 31.1 (28.1 to 34.1) | 32.7 (29.4 to 35.9) | 35.8 (32.0 to 39.7) | <0.0001 | <0.0001 | <0.0001 |
| Weight Z score* | 0.41 (−0.16 to 0.99) | 0.27 (−0.29 to 0.84) | 0.17 (−0.39 to 0.75) | 0.13 | 0.007 | 0.22 |
| Patients 12–18 yr of age (n=17) | ||||||
| BMI, kg/m2 | 21.9 (19.8 to 24.1) | 21.7 (19.8 to 23.7) | 22.3 (20.3 to 24.3) | 1.0 | 0.90 | 0.05 |
| BMI Z score | 0.90 (0.31 to 1.49) | 0.74 (0.16 to 1.31) | 0.72 (0.13 to 1.31) | 0.15 | 0.25 | 1.0 |
| Height, cm | 158.5 (154.6 to 162.5) | 162.1 (158.7 to 165.4) | 165.2 (162.2 to 168.3) | <0.0001 | <0.0001 | 0.0014 |
| Height Z score | 0.37 (−0.07 to 0.82) | 0.49 (0.07 to 0.90) | 0.50 (0.06 to 0.93) | 0.16 | 0.57 | 1.0 |
| Weight, kg | 55.3 (48.7 to 61.9) | 57.0 (51.7 to 62.3) | 60.8 (55.4 to 66.1) | 0.19 | 0.001 | 0.0002 |
Data are presented as means (95% confidence intervals). To compare the parameters between the subsequent visits, repeated measures analysis of variance testing was used.
*
Weight Z scores were calculated only for children up to 10 years of age, as weight-for-age reference data are not available beyond the age of 10 years.