TABLE 5.
Growth Parameters According to Sex in Pediatric Patients Treated With Sofosbuvir/Velpatasvir: At Baseline (0), 3 Months After the End of Treatment (1) and 12 Months After the End of Treatment (2)
| Parameter | 0 | 1 | 2 | P (0 vs. 1) | P (0 vs. 2) | P (1 vs. 2) |
|---|---|---|---|---|---|---|
| Girls (n=26) | ||||||
| BMI, kg/m2 | 18.8 (17.0 to 20.6) | 18.9 (17.2 to 20.6) | 19.3 (17.5 to 21.1) | 1.0 | 0.06 | 0.009 |
| BMI Z score | 0.36 (−0.13 to 0.87) | 0.31 (−0.14 to 0.77) | 0.28 (−0.17 to 0.75) | 1.0 | 0.83 | 1.0 |
| Height, cm | 144.4 (137.6 to 151.3) | 147.3 (140.6 to 154.1) | 150.6 (144.2 to 157.1) | <0.0001 | <0.0001 | <0.0001 |
| Height Z score | 0.61 (0.29 to 0.93) | 0.66 (0.36 to 0.96) | 0.64 (0.30 to 0.98) | 0.62 | 1.0 | 1.0 |
| Weight, kg | 41.2 (33.9 to 48.5) | 42.8 (35.9 to 49.6) | 45.6 (38.5 to 52.7) | 0.01 | <0.0001 | <0.0001 |
| Weight Z score* (n=9) | 0.19 (−0.33 to 0.73) | 0.11 (−0.49 to 0.67) | to 0.03 (−0.58 to 0.51) | 1.0 | 0.08 | 0.04 |
| Boys (n=23) | ||||||
| BMI, kg/m2 | 18.3 (16.7 to 19.8) | 18.1 (16.6 to 19.6) | 18.7 (17.1 to 20.2) | 0.95 | 0.31 | 0.01 |
| BMI Z score | 0.43 (−0.15 to 1.02) | 0.20 (−0.37 to 0.79) | 0.30 (−0.24 to 0.85) | 0.02 | 0.59 | 0.62 |
| Height, cm | 141.7 (136.5 to 146.9) | 145.4 (139.9 to 151.0) | 149.8 (143.8 to 155.8) | <0.0001 | <0.0001 | <0.0001 |
| Height Z score | 0.36 (−0.02 to 0.75) | 0.39 (0.03 to 0.76) | 0.40 (−0.04 to 0.85) | 1.0 | 1.0 | 1.0 |
| Weight, kg | 37.6 (32.6 to 42.7) | 39.3 (33.9 to 44.7) | 43.2 (37.2 to 49.3) | 0.0009 | <0.0001 | <0.0001 |
| Weight Z score* (n=7) | 0.70 (−0.65 to 2.05) | 0.47 (−0.85 to 1.81) | 0.45 (−0.86 to 1.77) | 0.19 | 0.17 | 1.0 |
Data are presented as means (95% confidence intervals).
*
Weight Z scores were calculated only for children up to 10 years of age, as weight-for-age reference data are not available beyond the age of 10 years.