Table 4.

Comparison of Administration of Insulin Glargine Before Versus After Initiation of Insulin Infusion in the Early Administration Group

Index Admission*	Before Infusion (n = 16)	After Infusion (n = 29)	p value
Age, median (IQR), yr	11 (9–14)	10 (8–13)	0.6438
Female, n (%)	5 (31)	11 (38)	0.7519
New-onset T1DM, n (%)	5 (31)	21 (72)	0.0118
All Admissions †	Before Infusion (n = 16)	After Infusion (n = 34)	p value
Blood glucose, median (IQR), mg/dL	360 (273–427)	502 (411–597)	0.0005
CO2, median (IQR), mEq/L	12 (9–14)	9 (9–12)	0.1116
Time until CO2 >15 mEq/L, median (IQR), hr	8.16 (5.45–10.52)	8.76 (5.95–12.85)	0.3938
Insulin infusion duration, median (IQR), hr	16.6 (10.3–25.3)	16.3 (13.4–21.8)	0.7869
Any adverse event, n (%)	11 (69)	21 (62)	0.7568
Hypoglycemia, n (%)	8 (50)	14 (41)	0.5577
Hypokalemia, n (%)	5 (31)	16 (47)	0.3653
Cerebral edema, n (%)	1 (6)	0	0.3200
Both hypoglycemia and hypokalemia, n (%)	2 (13)	9 (26)	0.4657

CO2, serum sodium bicarbonate concentration; T1DM, type 1 diabetes mellitus

^* Baseline demographic data were evaluated only for unique patients during their initial qualifying admission; repeated admissions were not evaluated for these baseline characteristics.

^† All admissions were included.