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. 2024 Nov 22;20(15):6255–6278. doi: 10.7150/ijbs.100113

Figure 5.

Figure 5

PKH26-labeled hiPSC-derived extracellular vesicles uptake on neuronal cells. Confocal images show representative fluorescent signals from DAPI (405, shown in blue), MAP2 (647, shown in red) and PKH26 (561, shown in green) of neuronal cells upon 24h incubation with PKH26-hiPSC-sEV. In (A) are shown two-dimensional projection of single and overlayed signals (objective 63X/1.30 GLYC); scale bars 20 µm. In (B) representative orthogonal views, xy, xz, yz (objective 63X/1.30 GLYC) displaying the intracellular presence of PKH26-hiPSC-EVs. Abbreviations: MAP2: microtubule-associated protein 2; hiPSC-sEV: hiPSC-derived small extracellular vesicles; GLYC: glycerol.