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. 2024 Nov 14;16(12):3089–3112. doi: 10.1038/s44321-024-00169-0

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© The Author(s) 2024

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. Creative Commons Public Domain Dedication waiver http://creativecommons.org/publicdomain/zero/1.0/ applies to the data associated with this article, unless otherwise stated in a credit line to the data, but does not extend to the graphical or creative elements of illustrations, charts, or figures. This waiver removes legal barriers to the re-use and mining of research data. According to standard scholarly practice, it is recommended to provide appropriate citation and attribution whenever technically possible.

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Figure EV4 — (A) The significantly changed metabolites between gastric cancer (n = 10) and normal tissues (n = 10). (B) Metabolites that partially or completely return to normal levels after surgery (n = 50 per group). (C) Volcano plot showing the lipids that were differentially expressed between GC and normal regions. (D) Top 10 lipid-related metabolic pathways highly expressed in cancer tissues and normal tissues according to the transcriptome and proteome analysis. P values were determined by T test (A–D) and adjusted via the Benjamini-Hochberg procedure (D). The definitions of box plots in (A) and (B) were consistent with those in Fig. 3A,B. AS after surgery, BS before surgery, HD healthy donor, SLMS serum lipid metabolic signature.