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. 2024 Dec 9;10:125. doi: 10.1038/s41421-024-00748-y

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© The Author(s) 2024

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 3 — a Cluster plot illustrating the temporal dynamics of protein phosphorylation across different time points during SARS-CoV-2 variant infections. A comprehensive comparison was conducted between variants and mock cells to identify the variant-specific upregulation (red) or downregulation (blue). The numbers above the arrows represent the unique proteins detected in each boxed upregulated cluster. b, c Selected clusters of consistently upregulated phosphorylation events were analyzed for Reactome pathway enrichment (b) and GO Biological Process enrichment (c) using the DAVID functional annotation tool. The top 10 enriched pathways and processes, ranked by count, are shown with their respective adjusted P-values (Benjamini). An asterisk adjacent to each bar indicates a statistically significant enrichment threshold (P < 0.05), with the corresponding adjusted P-value.