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. 2024 Jul 24;57(12):e13718. doi: 10.1111/cpr.13718

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© 2024 The Author(s). Cell Proliferation published by Beijing Institute for Stem Cell and Regenerative Medicine and John Wiley & Sons Ltd.

This is an open access article under the terms of the http://creativecommons.org/licenses/by/4.0/ License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.

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Premeiotic Eif2s2 deletion in oocytes causes downregulation of dictyate genes. (A) Pie chart showing the number and percentage of upregulated, downregulated and unchanged dictyate genes in Eif2s2 ^cKO mouse pro‐oocytes. (B) The relative expression of representative downregulated dictyate genes in pro‐oocyte clusters of Eif2s2 ^cKO mouse ovaries. (C) Violin plots of Tuba1c and tubb2b expression in Eif2s2 ^fl/fl and Eif2s2 ^cKO pro‐oocytes at 1 dpp. (D) Immunostaining of α‐tubulin (green) and DDX4 (red), and TRP63 (red) and DDX4 (green) in Eif2s2 ^fl/fl and Eif2s2 ^cKO mouse ovaries. DAPI, blue. (E) Western blotting (WB) analysis of TRP63 expression within Eif2s2 ^fl/fl and Eif2s2 ^cKO mouse ovaries. β‐actin was utilized as an internal control. n = 3. Scale bars: 10 μm. Bars represent the mean ± SD. A two‐sided Student's t‐test was performed to determine p values (*p < 0.05, **p < 0.01 and ***p < 0.001).