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. 2024 Sep 14;14(11):4819–4831. doi: 10.1016/j.apsb.2024.09.007

Figure 1.

Figure 1

Phosphoglycerate mutase 1 (PGAM1) up-regulation correlates with M2 tumor-associated macrophages (M2-TAMs) levels in human colon cancer. (A) The expression of PGAM1 was analyzed in normal (n = 345) and tumor (n = 290) tissues of colon cancer using the Cancer Genome Atlas (TCGA) and the Genotype-Tissue Expression (GTEx) database. (B) The expression of PGAM1 was analyzed in normal liver tissue and liver metastasis lesions of colon cancer patients using the GSE41258 (n = 8). (C) The correlation analysis between PGAM1 and enrichment of immune cells in TCGA colon adenocarcinoma database (n = 480). (D) The correlation analysis between PGAM1 and M2-TAMs in the TCGA colon adenocarcinoma database (n = 480). (E) The TCGA colon adenocarcinoma database was stratified into high- and low-PGAM1 expression groups, and CD163 expression in two groups was presented by heatmap (n = 480). (F) The association between PGAM1 and SPP1 in TCGA colon adenocarcinoma database (n = 480). ∗∗P < 0.01; ∗∗∗∗P < 0.0001.