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. 2024 Sep 14;14(11):4819–4831. doi: 10.1016/j.apsb.2024.09.007

Figure 5.

Figure 5

HKB99 perturbs liver metastases and reduces M2-TAMs in CT26-luc tumors. (A) The luciferin-based bioluminescence signal was measured via IVIS spectrum in the murine intrasplenic liver metastasis model on Day 1 and Day 19 after CT26-luc cells injection. HKB99 was injected at a dose of 50 (mg/kg body weight, mpk) daily starting on Day 8 after the CT26-luc injection. (B) The statistical results of (A). (C) The image of CT26-luc liver metastases. (D) The quantification of liver metastatic foci for (C). (E) The typical tiled image of the whole liver section of H&E staining showed the colon cancer liver metastases as indicated. Scale bars, 1 mm. (F) The IHC staining of CD8 and CD206. Scale bars, 100 μm. (G, H) The statistical result of (F). Data are presented as mean ± SEM (n = 5 for each group). ∗∗P < 0.01; ∗∗∗∗P < 0.0001.