Figure 6.

HKB99 exerts an anti-tumor effect partially dependent on inhibiting M2-TAMs infiltration. (A) Tumor growth curve of MC38 tumor in C57BL/6 mice. Lipo-Clo was administered at 50 mpk every 3 days starting 2 days before HKB99 treatment. HKB99 was injected at a dose of 50 mpk daily. Lipo-PBS and Vehicle were used as Lipo-Clo and HKB99's control respectively. (B) the relative size of HKB99-treated tumors compared with the vehicle-treated group with Lipo-PBS or Lipo-Clo administration respectively. (C) Tumor weight as indicated. (D) The image of MC38 tumors. (E) The H&E and IHC staining of the MC38 tumor section with CD206 and CD8 was indicated. Scale bars, 50 μm. Data, mean ± SEM (n = 6 for each group). ∗∗P < 0.01; ∗∗∗∗P < 0.0001, ns, non-significant.