Figure 2.

Solution scattering of synapsin ($6\mu \mathrm{M}$, TRIS buffer), shown in different representations. (a) Azimuthal average of the data measured at a sample-detector distance of 3 and 10 m with an acquisition time of 0.1 s after background subtraction. The darker colored points in the 3 m curve were discarded due to noise. For further analysis, a merged curve with contributions from both distances was used. The low q data are indicative for the formation of condensates. (b) Guinier representation of the merged curve, the radius of gyration is determined to $R_{\mathrm{g}}=4.2$ nm. The fitting was performed in a range between $q_{\min }=0.075{\text{nm}}^{-1}$ and $q_{\max }=0.31{\text{nm}}^{-1}$. (c) Kratky representation of the merged curve. The shape of the curve—which shows a distinct maximum that decays into a plateau-like region instead of a bell-shaped curve—indicates a solution of partially unfolded proteins.