Table 1.

Comprehensive reference table detailing the impact of CXCR1/2, CCR2, CXCR4, and GPR35 on tumor immunobiology across immune cell recruitment, angiogenesis, and cancer cell dynamics within the TME.

GPCRs	Immune cell recruitment to TME	Angiogenesis	Cancer cell proliferation, survival, invasion
CXCR1 CXCR2	Acharyya et al. [20] Li et al. [18] Teijeira et al. [19]	Keane et al. [22] Yang et al. [21] Ijichi et al. [23]	Maeda et al. [32] Miyamoto et al. [35] Wang et al. [34]
CCR2	Qian et al. [42] Li et al. [40] Nywening et al. [39]	Salcedo et al. [49] Izhak et al. [48] Bartneck et al. [47] Pausch et al. [44]	Fang et al. [53] Macanas‐Pirard et al. [52] Fein et al. [54]
CXCR4	Arwert et al. [57] Chiodoni et al. [60] Steele et al. [58]	Orimo et al. [66] Xu et al. [62] Du et al. [63]	Muller et al. [68] Murakami et al. [71] Darash‐Yahana et al. [67]
GPR35	Shu et al. [99] Yue et al. [92]	McCallum et al. [101] Pagano et al. [98] Li et al. [100]	Wang et al. [104] Schneditz et al. [105]

Abbreviation: TME, tumor microenvironment.