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. 2024 Sep 18;54(12):2451189. doi: 10.1002/eji.202451189

Figure 1.

Figure 1

Frequency and function of MAITs in patients with APECED. (A) Frequency of blood CD3+CD161++Vα7.2 MAITs in controls (open circle) and patients with APECED (black circle). (B) A representative flow cytometry plot for MAIT cell frequency of CD3+ T cells for control and a patient is shown. (C) Frequency of CD4−CD8+, CD4+CD8−, and CD4−CD8− double negative (DN) cells of MAITs in controls and patients. (D) Frequency of CD45RA+, CD57+, PD1+, and CD69+ cells of MAITs in controls and patients. (E) Frequency of IFN‐γ+ and (F) CD69+ MAITs without stimulation, after stimulation with C. albicans (CA), and after stimulation with PMA in controls and patients. The gating strategy for (A–D) is shown in Supporting Information Fig. S1A and for (E and F) in Supporting Information Fig. S2. Statistical significance was calculated with Mann–Whitney U‐test; *p < 0.05, **p < 0.01, ***p < 0.001, ns. = non‐significant.