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(a) Pipeline of generation and registration of WM masks in CSVD. WM masks within the dashed line were in the cross-time template space and (b) a schematic diagram of stable WMH and stable NAWM. LST: Lesion Segmentation Toolbox; LPA: lesion prediction algorithm; SAMSEG: Sequence Adaptive Multimodal SEGmentation; WM: white matter; WMH: white matter hyperintensities; NAWM: normal appearing WM.
