. Author manuscript; available in PMC: 2024 Dec 10.

Published in final edited form as: Neurotoxicol Teratol. 2024 Jan 8;101:107317. doi: 10.1016/j.ntt.2023.107317

Table 2.

Challenged with ethanol CDR Neurochemistry by Region.

CDR Group Comparison	Region	Neurocomponent	Main Effects			Two-Way Interactions			Three-way Interaction
CDR Group Comparison	Region	Neurocomponent	Tol	Age	Drug	Tol x Age	Tol x Drug	Age x Drug	Tol x Age x Drug
ETOH Vs. Saline	mPFC	DA	×	×	×	×	×	×	×
		NE		^***	^*
		5-HT			^*
		DOPAC	×	×	×	×	×	×	×
		HVA	×	×	×	×	×	×	×
		3-MT	×	×	×	×	×	×	×
		5-HIAA			^***
		DOPAC/DA Ratio	×	×	×	×	×	×	×
		5-HIAA/5-HT Ratio			^#		^#	^#
	NAc	DA			^#			^{^}
		NE		^**
		5-HT		^**
		DOPAC		^*				^*
		HVA						^#
		3-MT	×	×	×	×	×	×	×
		5-HIAA
		DOPAC/DA Ratio			^***
		5-HIAA/5-HT Ratio		^**
	dStr	DA		^***			^*		^*
		NE		^***	^***			^**	^#
		5-HT			^**			^*
		DOPAC		^**			^#		^{^}
		HVA		^**			^#
		3-MT		^#	^*
		5-HIAA		^*	^***			^*
		DOPAC/DA Ratio		^***	^**			^*
		5-HIAA/5-HT Ratio			^*				^{^}
	VTA	DA
		NE
		5-HT
		DOPAC						^{^}
		HVA	^*					^{^}
		3-MT	×	×	×	×	×	×	×
		5-HIAA			^*
		DOPAC/DA Ratio							^{^}
		5-HIAA/5-HT Ratio			^*

CDR Neurochemistry by Drug and Region. These tables present a representation of the significance threshold for each main effect and interaction of each neuro-component following repeated toluene and cumulative dosing. The “x” symbol represents that the component was below our detection threshold; the stars represent their typical cutoff thresholds of <0.001 (***), <0.01 (**), <0.05 (*); the “#” represents scores that fall above 0.05 but below 0.075 (e.g. 0.05 < score < 0.075); and lastly the “^” represents scores above 0.075 but <0.099 (e.g. 0.075 < score < 0.099). Table cells that don’t have a symbol in them were within the detection range but whose p-values fell above 0.1. Minimum value for inclusion was above 3 times the background (PCA) and was calculated using the curve created by a set of external standards for each component analyzed.