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. 2024 Sep 6;147(12):4026–4032. doi: 10.1093/brain/awae288

Figure 1.

Figure 1

Diffusion tensor imaging analysis along the perivascular space (DTI-ALPS) index in amyotrophic lateral sclerosis (ALS), primary lateral sclerosis (PLS) and control participants and DTI-ALPS index over time. (A) ALS participants have significantly reduced DTI-ALPS index in comparison with both controls and PLS participants. This includes aggregated data from images at the baseline, 4-month and 8-month time points (P = 0.002). (B) Longitudinal representation of the data across the three time points (mean ± standard deviation). DTI-ALPS is reduced in ALS participants compared to PLS and control participants at all three time points. We observe a statistically significant difference in the pattern of change over time at the 8-month time point for cases versus controls (P = 0.05).