Figure 3.

White matter hyperintensity burden and diffusion tensor imaging analysis along the perivascular space (DTI-ALPS). Using the scale developed by Fazekas et al.^12,13 (0–6 points, with a higher score indicating a higher lesion burden), the majority of scans included in this study had a low lesion burden. There was no significant difference in the scores between controls and amyotrophic lateral sclerosis (ALS) participants. At a higher lesion burden (4 points and above), there are only three scans, which are all from the same participant. Because most participants in this longitudinal study had multiple scans, the number of scans exceeds the number of participants in the study; n indicates the number of scans.