Table 1.

Participant characteristics

	ALS participants	PLS participants	Controls	Total
Number of participants (female/male)	18 (8/10)	5 (2/3)	22 (12/10)	45 (23/22)
Age, mean (SD)	57.6 (11.7)	58.8 (2.6)	56.6 (8.8)	57.3 (9.6)
Limb onset: bulbar onset (for ALS cases)	15:3	–	–	–
ALSFRS-R score, mean (SD)	34.53 (7.5)	34.40 (3.2)	N/A	N/A
Estimated progression rate (ALSFRS-R point loss per month), mean (SD)	0.52 (0.37)	0.25 (0.14)	N/A	N/A
Disease duration in months from symptom onset, mean (SD)	37.4 (27.0)	86.9 (79.4)	N/A	N/A

ALS = amyotrophic lateral sclerosis; ALSFRS-R = ALS Functional Rating Scale-Revised; PLS = primary lateral sclerosis; SD = standard deviation.