Skip to main content
. 2024 Dec 5;8(2):e202402757. doi: 10.26508/lsa.202402757

Figure 5. RuvBL co-expression decreases dipeptide repeat levels in a Drosophila model of C9ALS/FTD.

Figure 5.

(A, B, C, D) Drosophila pan-neuronally (nSyb-Gal4) co-expressing UAS-mKate2.CAAX (mKate), UAS-Pontin (Pontin), or UAS-Reptin (Reptin) with either UAS-GA(1020)eGFP (GA1000) (A), UAS-GR(1136)eGFP (GR1000) (B), UAS-PR(1100)eGFP (PR1000) (C), or UAS-PA(1024)eGFP (P1000) (D) were aged to 7 DPE before heads were taken for protein extraction. Dipeptide repeats were analysed by MSD-ELISA and are presented relative to the mKate control (mean ± SEM, N = 3 [PA1000], 4 [GA1000 and PR1000], or 5 [GR1000] independent experiments; one-way ANOVA with Tukey post-test: *P < 0.05, **P < 0.01, ***P < 0.001, ns, non-significant).