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. 2024 Aug 20;120(15):1939–1952. doi: 10.1093/cvr/cvae173

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© The Author(s) 2024. Published by Oxford University Press on behalf of the European Society of Cardiology.

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (https://creativecommons.org/licenses/by/4.0/), which permits unrestricted reuse, distribution, and reproduction in any medium, provided the original work is properly cited.

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LV function (EF) assessed by MRI. (A) Representative four-chamber views at end-systole and end-diastole from vehicle-, single-dose-, and repeated-dose-treated pigs at 30 days after MI (before the 1st treatment, pre-Rx) and at 105 days after the 1st treatment (immediately before euthanasia, post-Rx). (B) LV EF at pre-Rx and post-Rx. (C) Δ EF at post-Rx vs. pre-Rx. Open circles represent individual pigs and bars/whiskers mean ± S.e.m. P values shown for absolute EF values (two-way repeated-measures ANOVA followed by Bonferroni multiple comparison tests, n = 9/10) and for Δ EF (one-way ANOVA followed by Bonferroni t-tests, n = 9/10).