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Model depicting the function of ZEB2 in the ischaemic heart. Upon cardiac ischaemia, ZEB2 is transcriptionally regulated by HIF1α and post-transcriptionally by miR-208a, resulting in transcriptional activation of Adcy6, which will trigger cardioprotective signalling by improving Ca2+ homeostasis, preventing cardiomyocyte hypertrophy and enhancing cardiac contractility.
