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. 2024 Dec 4;6(4):lqae156. doi: 10.1093/nargab/lqae156

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© The Author(s) 2024. Published by Oxford University Press on behalf of NAR Genomics and Bioinformatics.

This is an Open Access article distributed under the terms of the Creative Commons Attribution-NonCommercial License (https://creativecommons.org/licenses/by-nc/4.0/), which permits non-commercial re-use, distribution, and reproduction in any medium, provided the original work is properly cited. For commercial re-use, please contact reprints@oup.com for reprints and translation rights for reprints. All other permissions can be obtained through our RightsLink service via the Permissions link on the article page on our site—for further information please contact journals.permissions@oup.com.

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Figure 5. — Impact of technical biases reflected in count imbalances. Distributions of read pair counts and interaction distances for CHi-C data derived from MAC-M0 cells. (A) Distribution of read pair counts per interaction for unbalanced and balanced reference interactions. (B) Corresponding distributions of interaction distances. (C) Distribution of read pair counts per interaction for unbalanced interactions and balanced reference interactions selected based on identical maximum read pair counts per interaction. (D) Corresponding distributions of interaction distances. This figure only shows the data for other-baited (NE) interactions. We make comparable observations for baited-other (EN) interactions (Supplementary Figure S9).