表 2.

4组小鼠伤后各时间点全层皮肤缺损创面愈合率比较（%，x±s）

Comparison of the wound healing rates of full-thickness skin defects of mice in the four groups at each time point post injury

组别	样本量	4 d	8 d	12 d
注：PBS为磷酸盐缓冲液，GelMA为甲基丙烯酸酐化明胶，hUCMSC-sEV为人脐带间充质干细胞来源的小细胞外囊泡；对PBS组、单纯GelMA水凝胶组、单纯hUCMSC-sEV组和hUCMSC-sEV/GelMA水凝胶组小鼠创面分别行PBS注射、单纯GelMA水凝胶覆盖、hUCMSC-sEV悬液注射、hUCMSC-sEV/GelMA水凝胶覆盖；处理因素主效应，F=461.49，P=0.001；时间因素主效应，F=1 714.92，P<0.001；两者交互作用，F=76.83，P=0.001；P1值、P2值、P3值分别为单纯GelMA水凝胶组、单纯hUCMSC-sEV组、hUCMSC-sEV/GelMA水凝胶组与PBS组各时间点比较所得；P4值、P5值分别为单纯hUCMSC-sEV组、hUCMSC-sEV/GelMA水凝胶组与单纯GelMA水凝胶组各时间点比较所得；P6值为单纯hUCMSC-sEV组与hUCMSC-sEV/GelMA水凝胶组各时间点比较所得
PBS组	6	58.3±1.3	63.7±0.4	77.8±1.3
单纯GelMA水凝胶组	6	65.4±4.4	69.2±1.8	92.8±0.5
单纯hUCMSC-sEV组	6	67.8±0.9	75.7±0.4	97.2±0.6
负载hUCMSC-sEV的GelMA水凝胶组	6	80.2±2.6	97.9±0.6	100
F值		70.00	1 332.52	1 001.81
P值		<0.001	<0.001	<0.001
P1值		<0.001	<0.001	<0.001
P2值		<0.001	<0.001	<0.001
P3值		<0.001	<0.001	<0.001
P4值		0.076	<0.001	<0.001
P5值		<0.001	<0.001	<0.001
P6值		<0.001	<0.001	0.031