表 1.
3组小鼠皮下埋植具有不同拓扑结构的三维生物打印海藻酸钠-明胶复合水凝胶支架7 d后支架周围组织中3种蛋白的表达比较(x±s)
Comparison of the expressions of 3 proteins in the tissue surrounding the scaffolds of subcutaneously implanted three-dimensional bioprinted scaffolds of alginate-gelation composite hydrogels with different topological structures in 3 groups of mice after 7 days
组别 | 样本数 | CD68 | BMP-2 | TNF |
注:BMP-2为骨形态发生蛋白2,TNF为肿瘤坏死因子;T45、T60、T90中T指拓扑结构,45、60、90指三维生物打印支架时打印喷头的旋转角度;F值、P值为3组间各指标总体比较所得;P1值、P2值分别为T45组与T60组、T90组比较所得,P3值为T60组与T90组比较所得 | ||||
T45组 | 3 | 23.9±2.0 | 6.1±0.5 | 15.4±3.5 |
T60组 | 3 | 63.8±12.5 | 17.5±0.8 | 8.0±0.9 |
T90组 | 3 | 25.4±2.2 | 2.4±0.9 | 15.4±2.3 |
F值 | 27.58 | 177.60 | 8.95 | |
P值 | 0.001 | < 0.001 | 0.016 | |
P1值 | 0.002 | < 0.001 | 0.032 | |
P2值 | > 0.999 | 0.003 | > 0.999 | |
P3值 | 0.002 | < 0.001 | 0.031 |