Figure 1.

Pregnancy outcomes during the ozanimod clinical development program. (A) Patient pregnancy outcomes. (B) Partner pregnancy outcomes. ^aSeventy-nine outcomes resulted from 78 pregnancies because a twin pregnancy led to 1 live birth without congenital abnormality and 1 spontaneous abortion (ie, vanishing twin). ^bSome of the CD studies are still blinded, so it is unknown whether 3 patients received ozanimod or placebo. ^cIncludes 1 late intrauterine growth retardation with subsequent normal progress. ^dThirty outcomes resulted from 29 pregnancies because of a twin pregnancy that led to 2 premature births. ^eOne partner pregnancy was from a Crohns’ disease study, which is still blinded; it is unknown whether this patient received ozanimod or placebo.