Table 3.
Association of overall survival endpoint with inflammatory burden and physical activity status
| Inflammatory burden and physical activity status | 5-y overall survival rate (95% CI)a,b | 5-y risk difference (95% CI)a,c | P c | Hazard ratio (95% CI)a | P |
|---|---|---|---|---|---|
| Low inflammation | |||||
| Sufficient physical activity | 94.5 (89.6 to 97.0) | 0.0 (Referent) | — | 1.00 (Referent) | — |
| Insufficient physical activity | 90.1 (83.7 to 94.1) | −4.4 (−10.6 to 1.8) | .15 | 1.85 (0.87 to 3.94) | .11 |
| Intermediate inflammation | |||||
| Sufficient physical activity | 91.4 (87.4 to 94.2) | −3.1 (−8.0 to 1.8) | .24 | 1.61 (0.81 to 3.19) | .17 |
| Insufficient physical activity | 84.3 (77.9 to 89.2) | −10.2 (−15.8 to −4.6) | .002 | 3.03 (1.58 to 5.81) | <.001 |
| High inflammation | |||||
| Sufficient physical activity | 91.2 (85.0 to 94.7) | −3.3 (−9.6 to 3.0) | .29 | 1.64 (0.77 to 3.51) | .20 |
| Insufficient physical activity | 89.0 (83.8 to 92.8) | −5.5 (−10.8 to −0.1) | .056 | 2.08 (1.06 to 4.06) | .030 |
a
Adjusted for sex, extent of invasion through the bowel wall, nodal stage, prudent dietary pattern (time varying), chemotherapy random assignment, and pharmacotherapy random assignment. Continuous covariates were modeled linearly, and categorical covariates were modeled using the categories presented in Table 1. CI = confidence interval.
b
Covariates for predicting disease-free survival rates were set to the mean of the study population for continuous variables and most common category for categorical variables.
c
95% confidence intervals and P values were calculated via test of proportions.