Fig. 3.

The predefined binding site on β-lactamase TEM-1. TEM-1 is represented in the surface model, colored tan (PDB ID: 1s0w, chain A). As shown in the left panel, the docking box is shaded purple and encompasses the binding site of a small-molecule drug, clavulanate (displayed in the stick and ball model and colored green), and a portion of the binding site of the BLIP (shown in the ribbon model and colored gray). The two loops of BLIP binding in the TEM-1 active site are highlighted in blue. The right panel shows an example of a screened peptide bound to TEM-1.