Table 1.
Demographics and clinical features of the study cohort
| Control | svPPA | lvPPA | nfvPPA | PSP | CBS | P* | |
|---|---|---|---|---|---|---|---|
| N | 24 | 9 | 9 | 9 | 10 | 13 | - |
| Age (SD) | 65.8 (5.2) | 67.2 (4.3) | 68.9 (8.1) | 70.1 (6.4) | 68.4 (5.9) | 70.2 (4.4) | ns |
| Gender M:F | 11:13 | 5:4 | 6:3 | 4:5 | 5:5 | 7:6 | ns |
| Handedness R:L | 21:3 | 9:0 | 9:0 | 8:1 | 9:1 | 12:1 | ns |
| Ethnicity white:other | 24:0 | 9:0 | 9:0 | 9:0 | 9:0 | 9:0 | - |
| First language English:other | 24:0 | 9:0 | 9:0 | 8:1 | 9:0 | 9:0 | - |
| Age left education (SD) | 20.6 (3.3) | 19.3 (2.6) | 20.6 (4.1) | 16.6 (1.7) | 16.7 (1.7) | 17.4 (3.0) | <0.001 |
| Symptom duration in years (SD) | NA | 6.5 (2.5) | 3.0 (2.7) | 3.2 (2.9) | 4.1 (2.5) | 5.2 (4.0) | ns |
| Total MLSE (SD) | 98.3 (2.2) | 78.1 (4.7) | 68.1 (15.3) | 70.9 (15.5) | 87.9 (8.0) | 81.8 (14.3) | <0.001 |
| ACE-R (SD) | 96.0 (3.4) | 53.9 (8.2) | 46.7 (25.1) | 69.7 (15.1) | 80.5 (13.4) | 74.0 (17.6) | <0.001 |
Note: Mean and standard deviations are displayed. For MLSE and ACE-R, values indicate scores out of 100. *P-value for F-test of group difference by ANOVA. ACE-R, Addenbrooke’s Cognitive Examination Revised; CBS, corticobasal syndrome; lvPPA, logopenic variant primary progressive aphasia; MLSE, Mini Linguistic State Examination; nfvPPA, non-fluent variant primary progressive aphasia; ns, not significant, P > 0.1; PSP, progressive supranuclear palsy; SD, standard deviation; svPPA, semantic variant primary progressive aphasia.