Table 2:
Immunological parameters after transplantation.
| ADPKD complete n = 193 | ADPKD matched-pair n = 189 | Control matched-pair n = 189 | P value | |
|---|---|---|---|---|
| Cyclosporin A trough level | ||||
| Month 1–3, median (IQR) | 177 (162–195) | 177 (162–195) | 176 (155–196) | .562 |
| Month 4–12, median (IQR) | 110 (96–123) | 110 (95–122) | 112 (102–124) | .224 |
| Month >12, median (IQR) | 92 (84–102) | 91 (84–103) | 93 (84–103) | .733 |
| Tacrolimus trough level | ||||
| Month 1–3, median (IQR) | 9.95 (9.10–11.00) | 10.00 (9.10–11.00) | 9.83 (8.55–11.10) | .277 |
| Month 4–12, median (IQR) | 7.35 (6.50–8.25) | 7.32 (6.50–8.26) | 7.15 (6.35–8.35) | .719 |
| Month >12, median (IQR) | 6.00 (5.30–6.81) | 6.00 (5.30–6.82) | 6.00 (5.49–6.70) | .832 |
| Number of patients with rejection, n (%) | 43 (22.3) | 41 (21.7) | 41 (21.7) | |
| TCMR, n (%) | 38 (19.7) | 36 (19.1) | 33 (17.5) | .690 |
| ABMR, n (%) | 5 (2.6) | 5 (2.7) | 5 (2.7) | |
| Mixed TCMR/ABMR, n (%) | 1 (0.5) | 1 (0.5) | 5 (2.7) | .100 |
| Number of rejection episodes, mean ± SD | 0.25 ± 0.51 | 0.24 ± 0.51 | 0.29 ± 0.55 | .699 |
| TCMR, mean ± SD | 0.20 ± 0.40 | 0.19 ± 0.39 | 0.17 ± 0.38 | .691 |
| ABMR, mean ± SD | 0.03 ± 0.16 | 0.03 ± 0.16 | 0.03 ± 0.16 | |
| Mixed TCMR/ABMR, mean ± SD | 0.01 ± 0.07 | 0.01 ± 0.07 | 0.03 ± 0.17 | .101 |
| Rejection treatment | ||||
| Steroid pulse, n | 49 | 47 | 55 | .354 |
| Thymoglobulin, n | 2 | 2 | 4 | .410 |
| Bortezomib, n | 1 | 1 | 4 | .177 |
| Plasmapheresis/IVIG, n | 6 | 6 | 9 | .491 |
| Rituximab, n | 0 | 0 | 1 | .317 |
| WBC count (×109/l) | ||||
| Pretransplant, median (IQR) | 8.00 (6.26–9.97) | 7.97 (6.22–9.96) | 9.46 (7.73–11.77) | <.001 |
| Day 1–14, median (IQR) | 8.55 (6.82–10.25) | 8.41 (6.81–10.18) | 9.61 (7.89–11.19) | <.001 |
| Day 15–month 3, median (IQR) | 7.78 (6.43–9.48) | 7.74 (6.40–9.48) | 8.57 (6.75–10.11) | .011 |
| Month 4–12, median (IQR) | 6.23 (5.09–7.65) | 6.21 (5.09–7.56) | 7.17 (5.82–8.80) | <.001 |
Abbreviations: ABMR, antibody mediated rejection; ADPKD, polycystic kidney disease; IQR, interquartile range; IVIG, intravenous immunoglobulins; SD, standard deviation; TCMR, T cell mediated rejection.
Chi-square test for categorical variables; Mann–Whitney U-test for continuously distributed variables.