Table 3b:
UTI and urosepsis during the entire observation period: comparison between ADPKD patients and control subgroups.
| ADPKD a (n = 161) | Diabetic nephropathy (n = 16) | Vascular nephropathy (n = 18) | Primary glomerulopathy (n = 59) | Systemic disease b (n = 8) | Hereditary kidney disease b (n = 7) | Obstructive nephropathy/chronic pyelonephritis (n = 20) | Miscellaneous b (n = 12) | Undetermined (n = 21) | |
|---|---|---|---|---|---|---|---|---|---|
| Patients with UTI, n (%), P | 63 (39.1) | 6 (37.5), .938 | 4 (22.2), .234 | 9 (15.3), .002 | 1 (12.5) | 1 (14.3) | 10 (50.0), 0.318 | 4 (33.3) | 6 (28.6), 0.382 |
| UTI episodes per patient, mean ± SD, P | 0.8 ± 1.4 | 0.9 ± 1.7, 0.636 | 0.5 ± 1.1, 0.253 | 0.3 ± 0.7, 0.001 | 0.1 ± 0.4 | 0.1 ± 0.4 | 1.1 ± 1.6, 0.076 | 0.3 ± 0.5 | 0.6 ± 1.1, 0.041 |
| Patients with urosepsis, n (%), P | 34 (21.1) | 4 (25.0), 0.748 | 5 (27.8), 0.358 | 7 (11.9), 0.166 | 2 (25.0) | 2 (28.6) | 4 (20.0), 0.872 | 1 (8.3) | 3 (14.3), 0.434 |
| Urosepsis episodes per patient, mean ± SD, P | 0.3 ± 0.8 | 0.5 ± 1.0, 0.366 | 0.4 ± 0.6, 0.687 | 0.1 ± 0.3, 0.028 | 0.3 ± 0.5 | 0.3 ± 0.5 | 0.3 ± 0.7, 0.596 | 0.1 ± 0.3 | 0.2 ± 0.5, 0.097 |
| Patients with UTI or urosepsis, n (%), P | 71 (44.1) | 8 (50.0), 0.654 | 7 (38.9), 0.830 | 13 (22.0), 0.006 | 3 (37.5) | 2 (28.6) | 10 (50.0), 0.543 | 4 (33.3) | 6 (28.6), 0.178 |
| UTI and urosepsis episodes per patient, mean ± SD, P | 1.1 ± 1.9 | 1.5 ± 2.0, 0.349 | 0.8 ± 1.3, 0.548 | 0.4 ± 1.0, 0.001 | 0.5 ± 0.8 | 0.4 ± 0.8 | 1.4 ± 2.1, 0.032 | 0.4 ± 0.7 | 0.8 ± 1.3, 0.002 |
Patients were censored from the time at which both native kidneys had been removed. In 22 ADPKD patients and in 9 control patients both native kidneys had been removed before Tx resulting in 161 matched pairs (in three pairs both native kidneys had been removed before Tx in both, the ADPKD patient and the control patient).
Reference group.
Infection rates and number of infections were not compared to ADPKD patients because of limited group size.
P value for ADPKD patients versus control subgroups estimated by a conditional logistic regression model adjusted for unilateral nephrectomy before Tx.
Abbreviations: ADPKD, polycystic kidney disease; SD, standard deviation; Tx, transplantation; UTI, urinary tract infection.