Table 6:
Risk factors for death/death with functioning graft in ADPKD patients.
| Univariable | Multivariable b | |||||||
|---|---|---|---|---|---|---|---|---|
| Death/death with functioning graft | Yes n = 25 | No n = 168 | HR a | 95%CI | P value | HR a | 95%CI | P value |
| Recipient age at Tx, mean ± SD (per 5 years) | 60.6 ± 12.1 | 54.3 ± 9.7 | 1.50 | 1.20; 1.88 | <.001 | |||
| Waiting time, mean ± SD (per 12 months) | 69.8 ± 44.9 | 44.7 ± 40.9 | 1.14 | 1.05; 1.24 | .003 | 1.12 | 1.02; 1.23 | .017 |
| Female recipient, n (%) (yes vs no) | 11 (44.0) | 70 (41.7) | 1.05 | 0.47; 2.32 | .907 | |||
| Recipient diabetes mellitus, n (%) (yes vs no) | 6 (25.0) | 22 (13.2) | 1.40 | 0.55; 3.56 | .481 | |||
| Recipient BMI, mean ± SD (per 1 kg/m2) | 25.1 ± 3.9 | 26.1 ± 3.9 | 0.96 | 0.86; 1.08 | .504 | |||
| Recipient CCI score, mean ± SD (per 1 point) | 4.5 ± 1.5 | 3.5 ± 1.2 | 1.81 | 1.36; 2.41 | <.001 | 1.74 | 1.31; 2.31 | <.001 |
| Unilateral nephrectomy before Tx, n (%) (yes vs no) | 9 (36.0) | 52 (31.0) | 1.07 | 0.47; 2.44 | .865 | |||
| Bilateral nephrectomy before Tx, n (%) (yes vs no) | 4 (16.0) | 18 (10.7) | 1.36 | 0.47; 3.99 | .570 | |||
| Donor age, mean ± SD (per 5 years) | 58.2 ± 13.9 | 53.5 ± 13.9 | 1.16 | 1.01; 1.35 | .042 | |||
| Donor eGFRcr, mean ± SD (per 5 ml/min/1.73 m2) | 73.4 ± 29.0 | 84.9 ± 23.6 | 0.93 | 0.87; 0.99 | .040 | |||
| Living donor, n (%) (yes vs no) | 4 (16.0) | 64 (38.1) | 0.35 | 0.12; 1.02 | .054 | |||
| Preemptive Tx, n (%) (yes vs no) | 1 (4.0) | 22 (13.1) | c | |||||
| AB0 compatible Tx, n (%) (yes vs no) | 25 (100.0) | 152 (90.5) | c | |||||
| Rejection episode, n (%) (yes vs no) | 5 (20.0) | 38 (22.6) | 0.98 | 0.36; 2.64 | .970 | |||
| Patients with UTI or urosepsis, n (%) (yes vs no) | 15 (60.0) | 71 (42.3) | 2.01 | 0.90; 4.52 | .090 | |||
a
Hazard ratio estimated by Cox-proportional hazard model.
b
Multivariable model was identified by LASSO regression.
c
Parameter was not analyzed because of small population of cells in cross table.
Abbreviations: ADPKD, polycystic kidney disease; BMI, body mass index; CCI, Charlson Comorbidity Index; CI, confidence interval; eGFRcr, creatinine-based estimated glomerular filtration rate; HR, hazard ratio; SD, standard deviation; Tx, transplantation; UTI, urinary tract infection.