Table 8:
Risk factors for overall graft failure in ADPKD patients.
| Univariable | Multivariable b | |||||||
|---|---|---|---|---|---|---|---|---|
| Overall graft failure | Yes n = 42 | No n = 151 | HR a | 95%CI | P value | HR a | 95%CI | P value |
| Recipient age at Tx, mean ± SD (per 5 years) | 61.0 ± 11.0 | 53.5 ± 9.4 | 1.56 | 1.30; 1.87 | <.001 | |||
| Waiting time, mean ± SD (per 12 months) | 60.4 ± 41.6 | 44.5 ± 41.8 | 1.10 | 1.02; 1.18 | .017 | 1.14 | 1.02; 1.27 | .025 |
| Female recipient, n (%) (yes vs no) | 20 (47.6) | 61 (40.4) | 1.17 | 0.63; 2.18 | .625 | |||
| Recipient diabetes mellitus, n (%) (yes vs no) | 7 (17.1) | 21 (14.0) | 0.90 | 0.40; 2.07 | .812 | |||
| Recipient BMI, mean ± SD (per 1 kg/m2) | 25.6 ± 3.8 | 26.0 ± 4.0 | 1.01 | 0.93; 1.10 | .857 | |||
| Recipient CCI score, mean ± SD (per 1 point) | 4.4 ± 1.4 | 3.4 ± 1.2 | 1.76 | 1.40; 2.21 | <.001 | 1.41 | 1.08; 1.85 | .013 |
| Unilateral nephrectomy before Tx, n (%) (yes vs no) | 13 (31.0) | 48 (31.8) | 0.94 | 0.48; 1.83 | .858 | |||
| Bilateral nephrectomy before Tx, n (%) (yes vs no) | 5 (11.9) | 17 (11.3) | 1.00 | 0.39; 2.56 | .999 | |||
| Donor age, mean ± SD (per 5 years) | 61.1 ± 12.9 | 52.2 ± 13.6 | 1.26 | 1.12; 1.42 | <.001 | 1.18 | 1.03; 1.35 | .014 |
| Donor eGFRcr, mean ± SD (per 5 ml/min/1.73 m2) | 73.3 ± 26.6 | 86.3 ± 23.3 | 0.93 | 0.88; 0.98 | .006 | 0.99 | 0.92; 1.05 | .658 |
| Living donor, n (%) (yes vs no) | 7 (16.7) | 61 (40.4) | 0.34 | 0.14; 0.80 | .014 | 0.98 | 0.33; 2.94 | .976 |
| Preemptive Tx, n (%) (yes vs no) | 1 (2.4) | 22 (14.6) | c | |||||
| AB0 compatible Tx, n (%) (yes vs no) | 40 (95.2) | 137 (90.7) | 0.70 | 0.16; 2.96 | 0626 | |||
| Rejection episode, n (%) (yes vs no) | 17 (40.5) | 26 (17.2) | 2.59 | 1.36; 4.92 | .004 | 2.20 | 1.10; 4.40 | .026 |
| Patients with UTI or urosepsis, n (%) (yes vs no) | 26 (61.9) | 60 (39.7) | 2.47 | 1.28; 4.75 | .007 | |||
a
Hazard ratio estimated by Cox-proportional hazard model.
b
Multivariable model was identified by LASSO regression.
c
Parameter was not analyzed because of small population of cells in cross table.
Abbreviations: ADPKD, polycystic kidney disease; BMI, body mass index; CCI, Charlson Comorbidity Index; CI, confidence interval; eGFRcr, creatinine-based estimated glomerular filtration rate; HR, hazard ratio; SD, standard deviation; Tx, transplantation; UTI, urinary tract infection.