Table 9:
Factors influencing the eGFRcr course in ADPKD patients.
| Univariable | Multivariable b | |||||
|---|---|---|---|---|---|---|
| eGFRcr course | beta a | 95%CI | P value | beta a | 95%CI | P value |
| Recipient age at Tx (per 5 years) | −3.58 | −4.77; −2.39 | <.001 | 0.13 | −1.59; 1.85 | .879 |
| Waiting time (per 1 year) | −0.39 | −1.14; 0.37 | .313 | |||
| Female recipient (yes vs no) | −1.93 | −7.29; 3.42 | .479 | |||
| Recipient diabetes mellitus (yes vs no) | 0.80 | −6.72; 8.32 | .835 | |||
| Recipient BMI (per 1 point) | −0.26 | −0.94; 0.41 | .446 | |||
| Recipient CCI score (per 1 point) | −4.92 | −6.86; −2.98 | <.001 | −1.47 | −3.94; 1.00 | 0.245 |
| Unilateral nephrectomy before Tx (yes vs no) | 3.99 | −1.66; 9.64 | .166 | |||
| Bilateral nephrectomy before Tx (yes vs no) | 4.40 | −3.86; 12.66 | .296 | |||
| Donor age (per 5 years) | −3.36 | −4.18; −2.54 | <.001 | −2.69 | −3.54; −1.84 | <.001 |
| Donor eGFRcr (per 5 ml/min/1.73 m2) | 1.25 | 0.74; 1.76 | <.001 | 0.44 | −0.02; 0.90 | .063 |
| Living donor (yes vs no) | 11.81 | 6.52; 17.10 | <.001 | 7.38 | 1.98; 12.78 | .007 |
| Preemptive Tx (yes vs no) | 9.51 | 1.38; 17.65 | .022 | 0.35 | −6.96; 7.65 | .926 |
| AB0 compatible Tx (yes vs no) | −0.50 | −10.21; 9.20 | .919 | |||
| Rejection episode (yes vs no) | −13.42 | −19.46; −7.37 | <.001 | −13.07 | −17.98; −8.16 | <.001 |
| Patients with UTI or urosepsis (yes vs no) | −0.72 | −2.57; 1.13 | .444 | |||
a
eGFRcr in follow-up was analyzed by a multilevel mixed-effects linear regression model.
b
Multivariable model was identified by LASSO regression.
Abbreviations: ADPKD, polycystic kidney disease; BMI, body mass index; CCI, Charlson Comorbidity Index; CI, confidence interval; eGFRcr, creatinine-based estimated glomerular filtration rate; Tx, transplantation; UTI, urinary tract infection.