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. 2024 Oct 22;29(12):1095–e1778. doi: 10.1093/oncolo/oyae285
Number of patients screened Total of 59 across both groups before randomization
Number of patients enrolled 25
Number of patients evaluable for toxicity 24
Number of patients evaluated for efficacy 19
Evaluation method The number and proportion of patients without CIPN (any grade) of the hands at the completion of 84 days of chemotherapy treatment
Response duration 15/19 (78.8%) patients completed 84 days of treatment without neuropathy
Duration of treatment 84 days or until CIPN developed
Outcome notes In the traditional group, 15/19 patients (78.8%) completed 84 days of treatment without neuropathy. Overall mean compliance with home prescribed occupational therapy based on patient completed diary was 92.2% in 16/19 patients that returned their patient diaries. Four of 19 patients (21.1%) in traditional group developed CIPN, P = .721. Cumulative doses of albumin-bound paclitaxel and cisplatin per patient of those who developed CIPN are listed in Tables 1 and 2.
Patient characteristics, disease states, treatment dates, number of days on study, and time to onset of CIPN are detailed in Supplementary Table S1.
Results of a Kaplan-Meier analysis showed those in Traditional Group with a mean time-to-event of 75.8 days (90% CI: 68.5, 83.2). Fifteen of 19 (78.9%) in the traditional group were censored in the analysis as they did not develop CIPN while on study (Figure 2).