Figure 2. Adhesion Molecules that Govern Leukocyte Trafficking in Other Organs Are Not Required for CD8 T_E Accumulation in the Liver.

(A) Percentage of Cor93 CD8 T_E that accumulated within the liver 2 hr upon transfer into HBV replication-competent transgenic mice (H2^bxd) that were previously treated with anti-PSGL1, anti-CD62L or anti-CD62E Abs relative to control (control = 100%). n = 5; results are representative of two independent experiments. Similar results were obtained with Env28 CD8 T_E (data not shown).

(B) Percentage of Cor93 CD8 T_E that accumulated within the liver 2 hr upon transfer into HBV replication-competent transgenic mice (H2^bxd) that were previously treated with anti-VLA-4, anti-LFA-1 or anti-PECAM-1 Abs relative to control (control = 100%). n = 8; results are representative of two independent experiments. Similar results were obtained with Env28 CD8 T_E (data not shown).(C) Percentage of Cor93 CD8 T_E that accumulated WT CD44^−/− within the liver 2 hr upon transfer into HBV replication-competent transgenic mice (H2^bxd) that were previously treated with anti-VAP-1 Abs relative to control (control = 100%). n = 5; results are representative of two independent experiments. Similar results were obtained with Env28 CD8 T_E (data not shown).

(D) Percentage of CD44^−/− Cor93 CD8 T_E that accumulated within the liver 2 hr upon transfer into HBV replication-competent transgenic mice (H2^bxd) relative to WT Cor93 CD8 T_E (WT = 100%). n = 10; results are representative of two independent experiments.

(E) Percentage of PTX-treated Cor93 CD8 T_E that accumulated within the liver 2 hr upon transfer into HBV replication-competent transgenic mice (H2^bxd) relative to control Cor93 CD8 T_E (control = 100%). n = 5; results are representative of two independent experiments. Similar results were obtained with Env28 CD8 T_E (data not shown).

(F) Percentage of Cor93 CD8 T_E that accumulated within the liver 2 hr upon transfer into HBV replication-competent transgenic mice (H2^bxd) that were injected 24 hr earlier with 5 × 10⁶ Env28 CD8 T_E relative to control (control = 100%). n = 5; results are representative of two independent experiments.

(G) Percentage of PTX-treated Cor93 CD8 T_E (relative to untreated Cor93 CD8 T_E controls) that accumulated within the liver 2 hr upon transfer into HBV replication-competent transgenic mice (H2^bxd) that were treated 24 hr earlier with Env28 CD8 T_E. n = 5; results are representative of two independent experiments.

Results are expressed as mean ± SEM.

See also Figure S1.