TABLE 1.
Linear Regressions Evaluating Whether Restrictive Fluid Treatment Is Associated With 24-Hour Left Ventricular Global Longitudinal Strain, Change in Left Ventricular Global Longitudinal Strain, or Right Ventricular Free-Wall Longitudinal Strain
| Parameter | Estimate (95% CI) | p | n (%) |
|---|---|---|---|
| LV GLS | 96 (73.3) | ||
| Intercept | –20.97 | ||
| Restrictive fluid group | 1.219 (–0.775 to 3.214) | 0.228 | |
| 24-hr mean arterial pressure | 0.019 | ||
| 24-hr E/e′ | 0.139 | ||
| Congestive heart failure | 6.043 | ||
| Myocardial infarction | 0.775 | ||
| Change in LV GLS | 58 (44.3) | ||
| Intercept | –1.97 | ||
| Restrictive fluid group | 1.416 (–1.146 to 3.978) | 0.273 | |
| 24-hr mean arterial pressure | 0.043 | ||
| 24-hr E/e′ | –0.233 | ||
| Congestive heart failure | 5.002 | ||
| Myocardial infarction | 4.518 | ||
| Right ventricular free-wall longitudinal strain | 94 (71.8) | ||
| Intercept | –24.69 | ||
| Restrictive fluid group | 2.332 (–1.196 to 5.860) | 0.192 | |
| 24-hr E/e′ | 0.410 | ||
| Mechanical ventilation | 3.222 |
E/e′ = ratio of early diastolic mitral inflow velocity to early diastolic mitral annulus velocity, LV GLS = left ventricular global longitudinal strain.
There was no statistical difference between the randomized groups, liberal fluid vs. restrictive fluid, on LV GLS, change in LV GLS, or right ventricular free-wall longitudinal strain. Similar nonsignificant results were found in a sensitivity analysis when missing values were imputed.