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. 2024 Dec 9;2024(4):hoae065. doi: 10.1093/hropen/hoae065
The guideline group recommends that relatives of women with the FMR1 premutation or other identified genetic causes of POI should be offered genetic counselling and testing. GPP
Female relatives (such as sisters or daughters) of women with non-iatrogenic POI should be counselled that they are at increased risk of developing POI themselves.
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The guideline group recommends that female relatives (such as sisters or daughters) of women with non-iatrogenic POI are offered support regarding their increased risk of POI, and ovarian reserve testing may be helpful. GPP
The guideline group recommends that female relatives (such as sisters or daughters) of women with non-iatrogenic POI should be informed of the signs and symptoms of POI and should promptly seek medical advice if this occurs. GPP
The guideline group recommends that female relatives (such as sisters or daughters) of women with non-iatrogenic POI should be informed that there are no established methods for predicting or preventing POI. Some relatives may wish to consider family planning and fertility preservation options. GPP