Women with POI should be informed that POI without HT is associated with reduced life expectancy, largely due to cardiovascular disease.	STRONG ⊕⊕◯◯
HT is recommended for women with POI until the usual age of menopause for primary prevention to reduce the risk of morbidity and mortality, whether there are estrogen deficiency symptoms or not.	STRONG ⊕◯◯◯
The guideline group recommends that women with POI should be encouraged to adopt a healthy lifestyle (including avoiding smoking, having a healthy diet and regular physical activity, and maintaining a healthy weight range) to reduce cardiovascular risk.	GPP